Bone Abstracts

Objective: To examine the efficacy and safety of direct administration of zoledronate acid (ZOL) on local osteoporotic lesion of ovariectomized rats.Methods: Six weeks later after ovariectomy, 16 6-month-old female S.D. rats were divided into the two groups with no differences of body weight and BMD of the proximal tibia. In the group L, 50 μl ZOL at a dose of 67 μg/kg were locally injected into the bone marrow between the two dr...

Background: Boys with muscular dystrophy as presented by Duchenne muscular dystrophy (DMD) lose muscle strength and are usually confined to a wheelchair until 13 years. Furthermore they often have development of myogenic scoliosis, and scoliosis surgery is necessary to acquire sitting balance. Osteoporosis is one of the major concerns to perform surgical treatment. Patients with DMD or congenital muscular dystrophy (CMD) have fragile bones due to loss of ambulation, glucocorti...

Backgrounds: Ossification of the posterior longitudinal ligament (OPLL) is characterized by pathological ectopic ossification of the posterior longitudinal ligament. Development of OPLL induces compression myelopathy or radiculopathy by spinal stenosis and the loss of spinal flexibility by ankylosing spinal hyperosteosis (ASH). Although the etiology of OPLL has not been fully elucidated, systemic and local bone formation factors may play a role in the pathogenesis of OPLL. The...